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India’s cooling demand is projected to rise eightfold by 2037–38 due to rapid urbanization, economic growth, and climate change. Conventional cooling systems often fail to meet diverse thermal comfort needs. This study uses the JOS-3 thermoregulation model to quantify sensible and latent heat loss from 17 body segments under varying operative temperatures (15°C–36.4°C) and relative humidity levels (30%–70%). Results show sensible heat loss dominates at lower temperatures, while latent heat loss becomes significant at higher humidity. The head, hands, and feet exhibit the highest heat exchange rates, making them ideal for localized cooling, enhancing comfort, and improving PECS energy efficiency.