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BIOHULL is a mobile biocontainment research vessel designed to operate at the intersection of architecture, biosafety, and environmental science. Housed within a floating barge and supported by a fixed dry dock structure, the project integrates BSL-3 and BSL-4 laboratories, sample processing zones, and self-sustaining infrastructure such as HVAC systems, energy backup, and water treatment. The design emphasizes a clear spatial hierarchy—organizing spaces by risk level, controlling movement through airlocks and pressure zones, and separating personnel and specimen pathways. A carbon fiber roof, lofted over curved aluminum ribs, conceals a service zone for mechanical systems, allowing the interior to remain sealed and efficient. With its modular framework and adaptable systems, BIOHULL addresses the future needs of mobile scientific research and high-containment infrastructure in vulnerable coastal and remote environments.