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Rapid economic development in India has intensified the changes in natural land cover and thus affects the availability of water resources. The present study aims to analyze past land-use changes for three time periods and assess their impacts on water resources in the Musi river basin, Hyderabad. The Soil and Water Assessment Tool (SWAT), an open-source hydrological model was used to simulate hydrological processes and assess the impacts of land-use change on surface runoff, groundwater flow, lateral flow, percolation, and evapotranspiration in the basin. Various geospatial and statistical analysis has been carried out along with the modelling approach.